纳米人工骨的原理是国家"863""973"支持的攻关项目，是崔福斋教授课题组在对人骨骨痂和胚胎骨的分级结构和生物矿化过程的多年研究基础上发明的新型骨材料。它与原有传统人工骨材料的最大区别在于，修复后的骨头和人体骨完全一样，不会在体内留下植入物。它仿照人类的骨头生成的机理，采用自组装方法制备纳米晶羟基磷灰石或胶原复合的生物硬组织修复材料，使复合材料具有纳米级别的天然骨分级结构和天然骨的多孔结构。
"纳米人工骨"植入者一般经过几个月的时间就可将它完全吸收进人体，整个过程没有任何免疫和排异反应。而且这种材料的性能使大夫手术操作方便，与其他类型的骨修复材料价格相当。
除了用于腰椎管减压手术之后的腰椎固定和骨愈合，纳米人工骨的用途非常广泛，如由于外伤造成的骨折，由于创伤、感染造成的骨质缺损、骨质不连接或者是畸形愈合，还有骨肿瘤等骨的病变，乃至骨质疏松，都可以植入纳米人工骨帮助愈合和提高骨的硬度。
Artificial bone was prepared by compounding nano-hydroxyapatite with organic macromolecule materials or adding growth factors. It has good biocompatibility and biological activity. It imitates the structure of natural bone, including nano-hydroxyapatite and collagen composite, nano-bone-like apatite and polyamide polymer composite. Nano-artificial bone has the characteristics of high strength and flexibility, and its various properties are almost the same as human bone. It can be widely used in orthopaedic clinic.
The principle of nano-artificial bone is a key project supported by "863" and "973" of China. It is a new bone material invented by Professor Cui Fuzhai's Research Group on the grading structure and biomineralization process of human callus and embryonic bone. The biggest difference between this material and the traditional artificial bone material is that the repaired bone is exactly the same as the human bone, and it will not leave implants in vivo. It imitates the mechanism of human bone formation and uses self-assembly method to prepare nanocrystalline hydroxyapatite or collagen composite bio-hard tissue repair materials, so that the composite materials have nano-scale natural bone grading structure and porous structure of natural bone.
In general, nano-artificial bone implants can be absorbed into the human body in a few months without any immune and rejection reaction during the whole process. Moreover, the properties of this material make it easy for doctors to operate, and the price of this material is comparable to that of other types of bone repair materials.
In addition to lumbar fixation and bone healing after lumbar spinal decompression surgery, nano-artificial bone is widely used. For example, fracture caused by trauma, bone defect caused by trauma, infection, bone nonunion or malunion, bone lesions such as bone tumors, and even osteoporosis, nano-artificial bone can be implanted to help heal and improve the hardness of bone.
